UK doctors have released info on the long-term effects of too much ecstasy (and its combination with certain other controlled substances). The gentleman in question apparently took some 40,000 tablets over 10 years (around a dozen a day).
Short-term memory loss, while a serious consequence of such behavior, is also probably one of the funniest - he would repeatedly do certain activities, unaware that he had just done them, and only remembering his intent to do them.
Moral of the story - don't do drugs, but make video recordings of those that do.
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